Medical Microneedle

1st Generation 2nd Generation 3rd Generation 4th Generation
SOLID & Coated HOLLOW DISSOLVING SWELLABLE / EMBEDDABLE
  • The technique developed first
  • Drug applied on the surface
  • Needles removed after use
  • Connected to a syringe
  • Used for vaccination, etc.
  • A needle's diameter, 100μm or more
  • Soluble polymers used
  • Drug combined with needles
  • Biological stability guaranteed
  • Needles inserted into the skin
  • Incised regions sealed
  • Possible to control a drug release rate
  • A needle, if broken, can cause side effects.
  • They are being less used except for use for certain purposes.
  • The hollow type is also used for such purposes as blood collection.
  • Main items in domestic and overseas markets
  • Safe even if broken
  • Applied for cosmetic purposes
  • SNVIA's (Pusan National University) exclusive technology
  • Suitable for medical purposes
  • SNVIA’s platform technology (Air-Pocket type Embeddable Microneedle)
    - Accurate doze control
    - Sustained drug release
    - Lower the risk of infection & bleeding

Core technology

SWELLABLE

Existing Microneedles

확대

microneedle application an cause puncture marks, increasing the risk of infection and bleeding (staining data).

SNVIA’s Swellable Microneedles

확대

EMBEDDABLE

After patch attachment, a needle tip is safely embedded into the skin by the skin's shear force.

확대
  • Biodegradable microneedle tips loaded with drug are embedded in the skin.
  • An appropriate concentration of drug is released slowly over a certain time (for hours ~ days).
  • The formulation technology allows quick and various applications of new modified drugs.
  • Unlike existing microneedles, they minimize skin troubles caused by attachment for long hours.
  • A Korean patent is registered.

CONTROLLED RELEASE

Result of Sustained drug release from MN Tips

확대
  • The microneedle loading drug, after inserted into the skin, swells by absorbing body fluid.
  • From the inserted needle, drug is released slowly through diffusion by concentration difference.
  • It is possible to precisely control quantitatively the drug release rate and amount (hours to days).

TISSUE ADHESION

Strong Adhesion Regardless of Tissue Types

  • Swellable microneedles can be used as a tissue adhesive for their mechanical interlocking with tissue.
  • Swellable microneedles, once inserted, become expanded, enabling mechanical interlocking with tissue.
    - High adhesive strength to the skin and soft tissues (mucous membranes of the intestine, eye ball, and muscle)
확대
확대

Achieving more than 3.5 times higher tissue adhesion, compared with staples in skin graft fixation